Coloncancerapcpathway

Mutation of the adenomatous polyposis coli (APC) tumor suppressor gene initiates the majority of colorectal (CR) cancers. One consequence of this ...

由 B Li 著作 · 2023 · 被引用 2 次 — APC (adenomatous polyposis coli) gene mutation is a central initialization in colon cancer tumorigenesis. However, the connection between APC ...

由 NM Al-Thani 著作 · 2022 · 被引用 1 次 — Colon cancer is often driven by mutations of the adenomatous polyposis coli (APC) gene, an essential tumor suppressor gene of the Wnt β-catenin ...

由 H Shailes 著作 · 2022 · 被引用 9 次 — BackgroundMutations in the tumor suppressor gene Adenomatous Polyposis Coli (APC) are found in 80% of sporadic colorectal cancer (CRC) ...

由 PJ Morin 著作 · 2019 · 被引用 19 次 — APC-activated long noncoding RNA inhibits colorectal carcinoma pathogenesis through reduction of exosome production.

由 L Zhang 著作 · 2017 · 被引用 340 次 — Mutational loss of the APC C-terminal sequence is regarded as essential to the initiation of colon cancer through loss of APC tumor suppressive functions.

由 LN Kwong 著作 · 2009 · 被引用 321 次 — Colon cancer closely follows the paradigm of a single “gatekeeper gene.” Mutations inactivating the APC (adenomatous polyposis coli) gene are found in ~80% ...

由 G Smith 著作 · 2002 · 被引用 701 次 — This finding suggests that these mutations lie on alternate pathways of colorectal tumor development. The heterogeneous pattern of tumor mutations in our ...

由 HT Nguyen 著作 · 2018 · 被引用 305 次 — The adenoma-carcinoma sequence is caused by three major pathways: CIN, MSI and CIMP. ... The extent to which cancer has spread at the time of ...